Ultra-high field MRI provides increased SNR which can be leveraged to image the human brain at the mesoscopic scale. Additionally, contrasts such as ToF angiography and QSM have an additional boost in contrast when moving to higher field strengths. Leveraging 7T, we have been able to acquire some of the highest resolution human in vivo images to date, including MPRAGE at 250 µm, ToF angiography at 150 µm as well as 140 µm, and QSM at 330 µm isotropic resolution. All data is openly available (see below). Further, the corresponding publications as well as other selected high resolution studies are listed in the following.

Scientific contribution & selected publications

• Book chapter and review of motion correction for ultra-)high resolution MRI.

  Mattern H, Lüsebrink F, Speck O. High Resolution Structural Brain Imaging. in Motion Correction in MR: Correction of Position, Motion, and Dynamic Field Changes edited by van der Kouwe A and Andre J (2022); ISBN: 9780128244609

• Leveraging PMC to image pial arteries at 140 µm isotropic resolution.

  Bollmann S, Mattern H, Bernier M, Robinson SR, Park D, Speck O, Polimeni JR. Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography. eLife, 2022 DOI: 10.7554/eLife.71186

• Case report: Leveraging high resolution MRI to study inflammation and counteractions in a CAA patient.

  Schreiber S, John A-C, Werner C, Vielhaber S, Heinze H-J, Speck O, Würfel J, Behme D, Mattern H. Counteraction of inflammatory activity in CAA-related subarachnoid hemorrhage. Journal of Neurology 2022 DOI:10.1007/s00415-022-11437-9; *equal contribution

• Prospectively motion-corrected layer-specific fMRI

  Iamshchinina P, Kaiser D, Yakupov R , Hänelt D, Sciarra A, Mattern H, Lüsebrink F, Düzel E, Speck O, Weiskopf N, Cichy R. Perceived and mentally rotated contents are differentially represented in cortical layers of V1. Communications Biology, 2021 DOI: 10.1038/s42003-021-02582-4

• Leveraging PMC to create the human phantom: an openly available high resolution dataset.

  Lüsebrink F, Mattern H, Yakupov R, Acosta-Cabronero J, Ashtarayeh M, Oeltze-Jafra S, Speck O. Comprehensive ultrahigh resolution whole brain in vivo MRI dataset as a human phantom. Scientific Data, 2021 DOI: 10.1038/s41597-021-00923-w

• Improving QSM and QSM-based venograms at 7T with PMC. and QSM Study

  Mattern H, Sciarra A, Lüsebrink F, Acosta-Cabronero J, Speck O. Prospective motion correction improves high resolution quantitative susceptibility mapping at 7T. Magnetic Resonance in Medicine, 2018 DOI: 10.1002/mrm.27509

• PMC improves vessel depiction in high resolution ToF angiography acquired at 7T

  Mattern H, Sciarra A, Godenschweger F, Stucht D, Lüsebrink F, Rose G, Speck O. Prospective motion correction enables highest resolution time-of-flight angiography at 7T. Magnetic Resonance in Medicine, 2017 DOI: 10.1002/mrm.27033

• Using PMC to acquire MPRAGE data at 250 µm at 7T

  Lüsebrink F, Sciarra A, Mattern H, Yakupov R, Speck O. T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 µm. Scientific Data, 2017 DOI: 10.1038/sdata.2017.32

Open source and publicly available data

• Data of the highest resolution ToF angiography to date at 140μm isotropic resolution
• Data from the human phantom including ToF angiography and QSM-derived venograms
• Data for the 250 µm MPRAGE publication